[HTML][HTML] Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease [S]
JL McManaman, ES Bales, DJ Orlicky, M Jackman… - Journal of lipid …, 2013 - ASBMB
The cytoplasmic lipid droplet (CLD) protein perilipin-2 (Plin2) is expressed in multiple
nonadipose tissues, where it is thought to play a role in regulating their lipid storage
properties. However, the extent to which Plin2 functions in nutrient utilization and
metabolism, or how it influences the consequences of over-feeding, remains unclear. In this
study, we demonstrate that the absence of Plin2 prevents high-fat diet (HFD)-induced
obesity in male and female mice. This response is associated with increased formation of …
nonadipose tissues, where it is thought to play a role in regulating their lipid storage
properties. However, the extent to which Plin2 functions in nutrient utilization and
metabolism, or how it influences the consequences of over-feeding, remains unclear. In this
study, we demonstrate that the absence of Plin2 prevents high-fat diet (HFD)-induced
obesity in male and female mice. This response is associated with increased formation of …