[HTML][HTML] Chromosomal rearrangements and copy number abnormalities of TP63 correlate with p63 protein expression in lung adenocarcinoma
MC Aubry, A Roden, SJ Murphy, G Vasmatzis… - Modern Pathology, 2015 - Elsevier
The TP63 gene encodes a member of the p53 family of transcription factors. Although TP53
is a well-known tumor suppressor gene, the role of p63 in tumorigenesis is controversial.
Our group recently identified novel chromosomal rearrangements involving TP63 in
approximately 6% of peripheral T-cell lymphomas, which correlated with a p63+/p40−
immunohistochemical profile. As a subset of lung adenocarcinomas are p63+/p40−, we
undertook the current study to examine the presence of TP63 rearrangements and correlate …
is a well-known tumor suppressor gene, the role of p63 in tumorigenesis is controversial.
Our group recently identified novel chromosomal rearrangements involving TP63 in
approximately 6% of peripheral T-cell lymphomas, which correlated with a p63+/p40−
immunohistochemical profile. As a subset of lung adenocarcinomas are p63+/p40−, we
undertook the current study to examine the presence of TP63 rearrangements and correlate …
