Mammalian chromosome ends are protected by nucleoprotein structures called telomeres.
Telomeres ensure genome stability by preventing chromosome termini from being
recognized as DNA damage. Telomere length homeostasis is inevitable for telomere
maintenance because critical shortening or over-lengthening of telomeres may lead to DNA
damage response or delay in DNA replication, and hence genome instability. Due to their
repetitive DNA sequence, unique architecture, bound shelterin proteins, and high propensity …