The Fanconi anemia DNA repair pathway: structural and functional insights into a complex disorder
Mutations in any of at least sixteen FANC genes (FANCA–Q) cause Fanconi anemia, a
disorder characterized by sensitivity to DNA interstrand crosslinking agents. The clinical
features of cytopenia, developmental defects, and tumor predisposition are similar in each
group, suggesting that the gene products participate in a common pathway. The Fanconi
anemia DNA repair pathway consists of an anchor complex that recognizes damage caused
by interstrand crosslinks, a multisubunit ubiquitin ligase that monoubiquitinates two …
disorder characterized by sensitivity to DNA interstrand crosslinking agents. The clinical
features of cytopenia, developmental defects, and tumor predisposition are similar in each
group, suggesting that the gene products participate in a common pathway. The Fanconi
anemia DNA repair pathway consists of an anchor complex that recognizes damage caused
by interstrand crosslinks, a multisubunit ubiquitin ligase that monoubiquitinates two …
