The plethora of knowledge gained on myelodysplastic syndromes (MDS), a heterogeneous
pre-malignant disorder of hematopoietic stem cells, through sequencing of several pathway
genes has unveiled molecular pathogenesis and its progression to AML. Evolution of
phenotypic classification and risk-stratification based on peripheral cytopenias and blast
count has moved to five-tier risk-groups solely concerning chromosomal aberrations.
Increased frequency of complex abnormalities, which is associated with genetic instability …