[HTML][HTML] Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-β and mediates TIMP-1 up-regulation
M Yamanaka, D Shegogue, H Pei, S Bu… - Journal of Biological …, 2004 - ASBMB
Transforming growth factor-β (TGF-β) signaling plays a pivotal role in extracellular matrix
deposition by stimulating collagen production and other extracellular matrix proteins and by
inhibiting matrix degradation. The present study was undertaken to define the role of
sphingosine kinase (SphK) in TGF-β signaling. TGF-β markedly up-regulated SphK1 mRNA
and protein amounts and caused a prolonged increase in SphK activity in dermal fibroblasts.
Concomitantly, TGF-β reduced sphingosine-1-phosphate phosphatase activity. Consistent …
deposition by stimulating collagen production and other extracellular matrix proteins and by
inhibiting matrix degradation. The present study was undertaken to define the role of
sphingosine kinase (SphK) in TGF-β signaling. TGF-β markedly up-regulated SphK1 mRNA
and protein amounts and caused a prolonged increase in SphK activity in dermal fibroblasts.
Concomitantly, TGF-β reduced sphingosine-1-phosphate phosphatase activity. Consistent …