[HTML][HTML] Expression of the human apoE2 isoform in adipocytes: altered cellular processing and impaired adipocyte lipogenesis
ZH Huang, N Maeda, T Mazzone - Journal of Lipid Research, 2011 - ASBMB
Expression of apoE in adipocytes has been shown to have an important role in modulating
adipocyte triglyceride (TG) metabolism and gene expression that is independent of
circulating and extracellular apoE. The impact of adipocyte expression of common human
apoE isoforms was evaluated using adipocytes harvested from human apoE2,-3, and-4
knock-in mice. Expression of the apoE2 isoform was associated with an increase in
adipocyte apoE gene expression and apoE synthesis. Newly synthesized apoE2 was …
adipocyte triglyceride (TG) metabolism and gene expression that is independent of
circulating and extracellular apoE. The impact of adipocyte expression of common human
apoE isoforms was evaluated using adipocytes harvested from human apoE2,-3, and-4
knock-in mice. Expression of the apoE2 isoform was associated with an increase in
adipocyte apoE gene expression and apoE synthesis. Newly synthesized apoE2 was …