Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: a meta-analysis
Objective.—To examine more closely the association between apolipoprotein E (APOE)
genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and
racial denominations. Data Sources.—Forty research teams contributed data
onAPOEgenotype, sex, age at disease onset, and ethnic background for 5930 patients who
met criteria for probable or definite AD and 8607 controls without dementia who were
recruited from clinical, community, and brain bank sources. Main Outcome Measures …
genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and
racial denominations. Data Sources.—Forty research teams contributed data
onAPOEgenotype, sex, age at disease onset, and ethnic background for 5930 patients who
met criteria for probable or definite AD and 8607 controls without dementia who were
recruited from clinical, community, and brain bank sources. Main Outcome Measures …