JAK-STAT activity in peripheral blood cells and kidney tissue in IgA nephropathy
J Tao, L Mariani, S Eddy, H Maecker… - Clinical Journal of the …, 2020 - journals.lww.com
Results We found PBMCs to have upregulated pSTAT production at baseline in patients with
IgA nephropathy with a limited reserve to respond to cytokine stimulation compared with
controls. Increased staining in glomerular mesangium and endothelium was seen for Jak-2
and pSTAT1 and in the tubulointerstitial for JAK2, pSTAT1, and pSTAT3. Activation of the
Janus kinase signal transducer and activator of transcription pathway was further supported
by increased pSTAT1 and pSTAT3 scores in glomerular and tubulointerstitial sections of the …
IgA nephropathy with a limited reserve to respond to cytokine stimulation compared with
controls. Increased staining in glomerular mesangium and endothelium was seen for Jak-2
and pSTAT1 and in the tubulointerstitial for JAK2, pSTAT1, and pSTAT3. Activation of the
Janus kinase signal transducer and activator of transcription pathway was further supported
by increased pSTAT1 and pSTAT3 scores in glomerular and tubulointerstitial sections of the …