Gyrate atrophy of the choroid and retina: improved visual function following reduction of plasma ornithine by diet
MI Kaiser-Kupfer, FM De Monasterio, D Valle… - Science, 1980 - science.org
MI Kaiser-Kupfer, FM De Monasterio, D Valle, MK Walser, S Brusilow
Science, 1980•science.orgIn a patient with gyrate atrophy of the choroid and retina, an arginine-deficient diet has
reduced plasma ornithine concentration fivefold during the past 20 months. Subjective
improvement in her visual function was noted approximately 15 months after institution of the
diet. This has been documented by improvements in the electroretinogram, dark-adaptation,
and color vision. The improvement involves rod and, to a lesser extent, cone function. The
results, although preliminary and limited to a single patient, suggest that reduction of plasma …
reduced plasma ornithine concentration fivefold during the past 20 months. Subjective
improvement in her visual function was noted approximately 15 months after institution of the
diet. This has been documented by improvements in the electroretinogram, dark-adaptation,
and color vision. The improvement involves rod and, to a lesser extent, cone function. The
results, although preliminary and limited to a single patient, suggest that reduction of plasma …
In a patient with gyrate atrophy of the choroid and retina, an arginine-deficient diet has reduced plasma ornithine concentration fivefold during the past 20 months. Subjective improvement in her visual function was noted approximately 15 months after institution of the diet. This has been documented by improvements in the electroretinogram, dark-adaptation, and color vision. The improvement involves rod and, to a lesser extent, cone function. The results, although preliminary and limited to a single patient, suggest that reduction of plasma ornithine with a low arginine diet is beneficial in this disease.
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