Zika virus, microcephaly, and ocular findings

DM Moshfeghi, HA de Miranda… - JAMA ophthalmology, 2016 - jamanetwork.com
The authors in all 3 publications postulate direct ZIKV-induced ocular findings. However, it
remains unclear whether the ocular lesions described in these reports are a direct result of
ZIKV or a result of microcephaly itself. For 50 years, there has been well-documented history
(beginning in this very journal) 4 of both sporadic and heritable (autosomal recessive and
autosomal dominant) forms of microcephaly associated with ocular findings similar to those
recently attributed to ZIKV infection1-3: pigmentary maculopathy, circumscribed chorioretinal …