[HTML][HTML] Non-muscle myosin II and myosin light chain kinase are downstream targets for vasopressin signaling in the renal collecting duct
CL Chou, BM Christensen, S Frische, H Vorum… - Journal of Biological …, 2004 - ASBMB
We have previously demonstrated that vasopressin increases the water permeability of the
inner medullary collecting duct (IMCD) by inducing trafficking of aquaporin-2 to the apical
plasma membrane and that this response is dependent on intracellular calcium mobilization
and calmodulin activation. Here, we address the hypothesis that this water permeability
response is mediated in part through activation of the calcium/calmodulin-dependent myosin
light chain kinase (MLCK) and regulation of non-muscle myosin II. Immunoblotting and …
inner medullary collecting duct (IMCD) by inducing trafficking of aquaporin-2 to the apical
plasma membrane and that this response is dependent on intracellular calcium mobilization
and calmodulin activation. Here, we address the hypothesis that this water permeability
response is mediated in part through activation of the calcium/calmodulin-dependent myosin
light chain kinase (MLCK) and regulation of non-muscle myosin II. Immunoblotting and …