[HTML][HTML] Neutrophil diversity in health and disease

C Silvestre-Roig, ZG Fridlender, M Glogauer… - Trends in …, 2019 - cell.com
C Silvestre-Roig, ZG Fridlender, M Glogauer, P Scapini
Trends in immunology, 2019cell.com
New evidence has challenged the outdated dogma that neutrophils are a homogeneous
population of short-lived cells. Although neutrophil subpopulations with distinct functions
have been reported under homeostatic and pathological conditions, a full understanding of
neutrophil heterogeneity and plasticity is currently lacking. We review here current
knowledge of neutrophil heterogeneity and diversity, highlighting the need for deep
genomic, phenotypic, and functional profiling of the identified neutrophil subpopulations to …
New evidence has challenged the outdated dogma that neutrophils are a homogeneous population of short-lived cells. Although neutrophil subpopulations with distinct functions have been reported under homeostatic and pathological conditions, a full understanding of neutrophil heterogeneity and plasticity is currently lacking. We review here current knowledge of neutrophil heterogeneity and diversity, highlighting the need for deep genomic, phenotypic, and functional profiling of the identified neutrophil subpopulations to determine whether these cells truly represent bona fide novel neutrophil subsets. We suggest that progress in understanding neutrophil heterogeneity will allow the identification of clinically relevant neutrophil subpopulations that may be used in the diagnosis of specific diseases and lead to the development of new therapeutic approaches.
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