Neuropilin-1 is expressed on adult mammalian dorsal root ganglion neurons and mediates semaphorin3a/collapsin-1-induced growth cone collapse by small …
Neuropilin-1 on the growth cones of NGF-dependent embryonic dorsal root ganglion (DRG)
neurons mediates the repulsive effects of secreted semaphorin3a, but its role in adult
neurons is unknown. Here we show that most adult rat DRG neurons, regardless of cell
diameter/afferent phenotype, express neuropilin-1 protein in vitro. However, the response of
growth cones belonging to these neurons (induced by recombinant collapsin-
1/semaphorin3a and blocked by the anti-neuropilin-1 antibody) was restricted to those of …
neurons mediates the repulsive effects of secreted semaphorin3a, but its role in adult
neurons is unknown. Here we show that most adult rat DRG neurons, regardless of cell
diameter/afferent phenotype, express neuropilin-1 protein in vitro. However, the response of
growth cones belonging to these neurons (induced by recombinant collapsin-
1/semaphorin3a and blocked by the anti-neuropilin-1 antibody) was restricted to those of …
