[HTML][HTML] High frequencies of polyfunctional HIV-specific T cells are associated with preservation of mucosal CD4 T cells in bronchoalveolar lavage
JM Brenchley, KS Knox, AI Asher, DA Price… - Mucosal …, 2008 - Elsevier
The mechanisms underlying the massive gastrointestinal tract CD4 T-cell depletion in
human immunodeficiency virus (HIV) infection are not well understood nor is it clear whether
similar depletion is manifest at other mucosal surfaces. Studies of T-cell and virus dynamics
in different anatomical sites have begun to illuminate the pathogenesis of HIV-associated
disease. Here, we studied depletion and HIV infection frequencies of CD4 T cells from the
gastrointestinal tract, bronchoalveolar lavage (BAL), and blood with the frequencies and …
human immunodeficiency virus (HIV) infection are not well understood nor is it clear whether
similar depletion is manifest at other mucosal surfaces. Studies of T-cell and virus dynamics
in different anatomical sites have begun to illuminate the pathogenesis of HIV-associated
disease. Here, we studied depletion and HIV infection frequencies of CD4 T cells from the
gastrointestinal tract, bronchoalveolar lavage (BAL), and blood with the frequencies and …
