Fixing the breaks in intestinal stem cells after radiation: a matter of DNA damage and death or DNA repair and regeneration

PK Lund - Gastroenterology, 2012 - gastrojournal.org
Current concepts, reviewed in Scoville et al 1 and summarized in Figure 1 A suggest the
existence of 2 intestinal stem cell (ISC) populations. One comprises cells originally termed
crypt-based columnar cells (CBC) lying between Paneth cells at the crypt base. Elegant
studies from the Clevers group used novel reporter mice and lineage-tracing models 2 and
in vitro culture systems 3 to demonstrate that CBC are marked by expression of Lgr5 and
provide the first definitive evidence that Lgr5+-CBC are actively cycling ISC, multipotent for …