Despite many years of experimental studies on radiation-induced chromosomal aberrations,
and the recent progress in elucidating the molecular mechanisms of the DNA damage
response, the link between DNA double-strand break repair and its expression as
microscopically visible chromosomal rearrangements remains, in many ways, obscure.
Some long standing controversies have partially been resolved to the satisfaction of most
investigators, including the linearity of the dose–response for DNA double-strand break …