[HTML][HTML] Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal …
H Patil, A Saha, E Senda, K Cho, ME Haque… - Journal of Biological …, 2014 - ASBMB
Retinal pigment epithelium (RPE) degeneration underpins diseases triggered by disparate
genetic lesions, noxious insults, or both. The pleiotropic Ranbp2 controls the expression of
intrinsic and extrinsic pathological stressors impinging on cellular viability. However, the
physiological targets and mechanisms controlled by Ranbp2 in tissue homeostasis, such as
RPE, are ill defined. We show that mice, RPE-cre:: Ranbp2−/−, with selective Ranbp2
ablation in RPE develop pigmentary changes, syncytia, hypoplasia, age-dependent …
genetic lesions, noxious insults, or both. The pleiotropic Ranbp2 controls the expression of
intrinsic and extrinsic pathological stressors impinging on cellular viability. However, the
physiological targets and mechanisms controlled by Ranbp2 in tissue homeostasis, such as
RPE, are ill defined. We show that mice, RPE-cre:: Ranbp2−/−, with selective Ranbp2
ablation in RPE develop pigmentary changes, syncytia, hypoplasia, age-dependent …