[HTML][HTML] MicroRNA-processing enzymes are essential for survival and function of mature retinal pigmented epithelial cells in mice
TR Sundermeier, S Sakami, B Sahu, SJ Howell… - Journal of Biological …, 2017 - ASBMB
Age-related macular degeneration (AMD) is a major cause of irreversible vision loss. The
neovascular or" wet" form of AMD can be treated to varying degrees with anti-angiogenic
drugs, but geographic atrophy (GA) is an advanced stage of the more prevalent" dry" form of
AMD for which there is no effective treatment. Development of GA has been linked to loss of
the microRNA (miRNA)-processing enzyme DICER1 in the mature retinal pigmented
epithelium (RPE). This loss results in the accumulation of toxic transcripts of Alu …
neovascular or" wet" form of AMD can be treated to varying degrees with anti-angiogenic
drugs, but geographic atrophy (GA) is an advanced stage of the more prevalent" dry" form of
AMD for which there is no effective treatment. Development of GA has been linked to loss of
the microRNA (miRNA)-processing enzyme DICER1 in the mature retinal pigmented
epithelium (RPE). This loss results in the accumulation of toxic transcripts of Alu …