[HTML][HTML] Identification of tyrosine residues in vascular endothelial growth factor receptor-2/FLK-1 involved in activation of phosphatidylinositol 3-kinase and cell …
V Dayanir, RD Meyer, K Lashkari, N Rahimi - Journal of Biological …, 2001 - ASBMB
Activation of vascular endothelial growth factor receptor-2 (VEGFR-2) plays a critical role in
vasculogenesis and angiogenesis. However, the mechanism by which VEGFR-2 activation
elicits these cellular events is not fully understood. We recently constructed a chimeric
receptor containing the extracellular domain of human CSF-1R/c-fms, fused with the entire
transmembrane and cytoplasmic domains of murine VEGFR-2 (Rahimi, N., Dayanir, V., and
Lashkari, K.(2000) J. Biol. Chem. 275, 16986–16992). In this study we used VEGFR-2 …
vasculogenesis and angiogenesis. However, the mechanism by which VEGFR-2 activation
elicits these cellular events is not fully understood. We recently constructed a chimeric
receptor containing the extracellular domain of human CSF-1R/c-fms, fused with the entire
transmembrane and cytoplasmic domains of murine VEGFR-2 (Rahimi, N., Dayanir, V., and
Lashkari, K.(2000) J. Biol. Chem. 275, 16986–16992). In this study we used VEGFR-2 …