VEGF receptor signalling? In control of vascular function

AK Olsson, A Dimberg, J Kreuger… - … reviews Molecular cell …, 2006 - nature.com
AK Olsson, A Dimberg, J Kreuger, L Claesson-Welsh
Nature reviews Molecular cell biology, 2006nature.com
Vascular endothelial growth-factor receptors (VEGFRs) regulate the cardiovascular system.
VEGFR1 is required for the recruitment of haematopoietic precursors and migration of
monocytes and macrophages, whereas VEGFR2 and VEGFR3 are essential for the
functions of vascular endothelial and lymphendothelial cells, respectively. Recent insights
have shed light onto VEGFR signal transduction and the interplay between different
VEGFRs and VEGF co-receptors in development, adult physiology and disease.
Abstract
Vascular endothelial growth-factor receptors (VEGFRs) regulate the cardiovascular system. VEGFR1 is required for the recruitment of haematopoietic precursors and migration of monocytes and macrophages, whereas VEGFR2 and VEGFR3 are essential for the functions of vascular endothelial and lymphendothelial cells, respectively. Recent insights have shed light onto VEGFR signal transduction and the interplay between different VEGFRs and VEGF co-receptors in development, adult physiology and disease.
nature.com