Reversal of the low-affinity neurotrophin receptor stromal-epithelial expression pattern between benign and malignant human prostate

CN Papandreou, T Bogenrieder, CL Finstad… - … Oncology: Seminars and …, 1998 - Elsevier
Reduced expression of the low-affinity p75 neurotrophin receptor (p75NTR) occurs in
prostate epithelial cells during malignant transformation. Recent studies indicating that the
p75NTR can transduce signals that induce apoptosis suggest that diminished p75NTR in
transformed prostate cells may contribute to immortalization. Mutations in the
transmembrane domain of the p75NTR gene have been associated with decreased
p75NTR protein expression and may block the ability of the p75NTR to induce apoptosis …