Endocrine-paracrine cell types in the prostate and prostatic adenocarcinoma are postmitotic cells
H Bonkhoff, U Stein, K Remberger - Human pathology, 1995 - Elsevier
Neuroendocrine (NE) differentiation frequently occurs in common prostatic malignancies
and has potential prognostic and therapeutic implications. In a recent study we were able to
provide immunohistochemical evidence that endocrine-paracrine cell types represent an
androgen-insensitive cell population in prostate cancer, documented by the consistent lack
of the pertinent receptor. In this study we investigated the proliferative activity of endocrine-
paracrine cell types in normal, hyperplastic, and neoplastic prostate tissue. Using double …
and has potential prognostic and therapeutic implications. In a recent study we were able to
provide immunohistochemical evidence that endocrine-paracrine cell types represent an
androgen-insensitive cell population in prostate cancer, documented by the consistent lack
of the pertinent receptor. In this study we investigated the proliferative activity of endocrine-
paracrine cell types in normal, hyperplastic, and neoplastic prostate tissue. Using double …
