Impact of asymptomatic Herpes simplex virus-2 infection on T cell phenotype and function in the foreskin
JL Prodger, R Gray, G Kigozi, F Nalugoda… - Aids, 2012 - journals.lww.com
JL Prodger, R Gray, G Kigozi, F Nalugoda, R Galiwango, K Nehemiah, M Kakanga, T Hirbod…
Aids, 2012•journals.lww.comHerpes simplex virus type 2 (HSV-2) increases the risk of HIV acquisition in men and overall
CD4+ T cell density in the foreskin. Using tissues obtained during routine male circumcision,
we examined the impact of HSV-2 on the function and phenotype of foreskin T cells in
Ugandan men. HSV-2 infection was predominantly associated with a compartmentalized
increase in CCR5 expression by foreskin CD4+ T cells, which may contribute to HIV
susceptibility.
CD4+ T cell density in the foreskin. Using tissues obtained during routine male circumcision,
we examined the impact of HSV-2 on the function and phenotype of foreskin T cells in
Ugandan men. HSV-2 infection was predominantly associated with a compartmentalized
increase in CCR5 expression by foreskin CD4+ T cells, which may contribute to HIV
susceptibility.
Abstract
Herpes simplex virus type 2 (HSV-2) increases the risk of HIV acquisition in men and overall CD4+ T cell density in the foreskin. Using tissues obtained during routine male circumcision, we examined the impact of HSV-2 on the function and phenotype of foreskin T cells in Ugandan men. HSV-2 infection was predominantly associated with a compartmentalized increase in CCR5 expression by foreskin CD4+ T cells, which may contribute to HIV susceptibility.
Lippincott Williams & Wilkins