[HTML][HTML] A novel compound that elevates high density lipoprotein and activates the peroxisome proliferator activated receptor
CL Bisgaier, AD Essenburg, BC Barnett… - Journal of lipid …, 1998 - ASBMB
In the current studies we describe the effects of PD 72953 and related compounds on
lipoprotein levels in chowfed male rats. After 2 weeks, 10 mg/kg of PD 72953 daily was as
effective as 100 mg/kg gemfibrozil for elevating HDL-cholesterol. At 100 mg/kg, PD 72953
further elevated HDL-cholesterol to 232% of control levels, and was associated with
increased HDL size and plasma apoE (169% of control), despite no change in hepatic apoE
mRNA. ApoA-I rose transiently (at 1 week), but by 2 weeks only apoE remained elevated …
lipoprotein levels in chowfed male rats. After 2 weeks, 10 mg/kg of PD 72953 daily was as
effective as 100 mg/kg gemfibrozil for elevating HDL-cholesterol. At 100 mg/kg, PD 72953
further elevated HDL-cholesterol to 232% of control levels, and was associated with
increased HDL size and plasma apoE (169% of control), despite no change in hepatic apoE
mRNA. ApoA-I rose transiently (at 1 week), but by 2 weeks only apoE remained elevated …