[HTML][HTML] Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor γ and retinoid X …
SS Abu-Abed, BR Beckett, H Chiba… - Journal of Biological …, 1998 - ASBMB
We have cloned a mouse cDNA homolog of P450RAI, a cytochrome P450 belonging to a
new family (CYP26), which has previously been isolated from zebrafish and human cDNAs
and found to encode a retinoic acid-inducible retinoic acid hydroxylase activity. The cross-
species conservation of the amino acid sequence is high, particularly between the mouse
and the human enzymes, in which it is over 90%. Like its human and zibrafish counterparts,
the mouse P450RAI cDNA catalyzes metabolism of retinoic acid into 4-OH-retinoic acid, 4 …
new family (CYP26), which has previously been isolated from zebrafish and human cDNAs
and found to encode a retinoic acid-inducible retinoic acid hydroxylase activity. The cross-
species conservation of the amino acid sequence is high, particularly between the mouse
and the human enzymes, in which it is over 90%. Like its human and zibrafish counterparts,
the mouse P450RAI cDNA catalyzes metabolism of retinoic acid into 4-OH-retinoic acid, 4 …