[HTML][HTML] The retinoic acid hydroxylase Cyp26a1 has minor effects on postnatal vitamin A homeostasis, but is required for exogenous atRA clearance
The all-trans-retinoic acid (atRA) hydroxylase Cyp26a1 is essential for embryonic
development and may play a key role in regulating atRA clearance also in adults. We
hypothesized that loss of Cyp26a1 activity via inducible knockout in juvenile or adult mice
would result in decreased atRA clearance and increased tissue atRA concentrations and
atRA-related adverse effects. To test these hypotheses, Cyp26a1 was knocked out in
juvenile and adult male and female Cyp26a1 floxed mice using standard Cre–Lox …
development and may play a key role in regulating atRA clearance also in adults. We
hypothesized that loss of Cyp26a1 activity via inducible knockout in juvenile or adult mice
would result in decreased atRA clearance and increased tissue atRA concentrations and
atRA-related adverse effects. To test these hypotheses, Cyp26a1 was knocked out in
juvenile and adult male and female Cyp26a1 floxed mice using standard Cre–Lox …