HLA antigens in adults negative for antibody to Epstein‐Barr virus (EBV)

E Edmond, CM Steel, M Ennis, F Cameron… - Tissue …, 1981 - Wiley Online Library
E Edmond, CM Steel, M Ennis, F Cameron, H Dick
Tissue Antigens, 1981Wiley Online Library
Evidence for a genetic component in susceptibility to Epstein‐Barr virus (EBV) infection was
sought by comparing HLA A and B phenotypes of EBV antibody‐negative Scottish medical
students and randomly chosen antibody‐positive controls. No statistically significant
differences were observed, but three antigens,(AID, A29 and B15), were relatively
underrepresented in the EBV seronegative group; findings which agree with data previously
reported from a similar study in Los Angeles. A strong association between the HLA …
Evidence for a genetic component in susceptibility to Epstein‐Barr virus (EBV) infection was sought by comparing HLA A and B phenotypes of EBV antibody‐negative Scottish medical students and randomly chosen antibody‐positive controls. No statistically significant differences were observed, but three antigens, (AID, A29 and B15), were relatively underrepresented in the EBV seronegative group; findings which agree with data previously reported from a similar study in Los Angeles. A strong association between the HLA A1/Blank phenotype and EBV seronegativity, evident in the Los Angeles population, was not confirmed in the present study.
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