Epstein-Barr virus negativity among individuals older than 60 years is associated with HLA-C and HLA-Bw4 variants and tonsillectomy
B Durovic, O Gasser, P Gubser, J Sigle… - Journal of …, 2013 - journals.asm.org
Journal of virology, 2013•journals.asm.org
Epstein-Barr virus (EBV) infects∼ 95% of the adult population. The factors that confer
protection in the remaining∼ 5% remain unknown. In an exploratory study, we assessed
immunogenetic factors and tonsillectomy in a cohort of 17 EBV-negative and 39 EBV-
positive healthy individuals aged> 60 years. Analyses of HLA genotypes revealed an
association between EBV negativity and the presence of HLA-C-35T/T and/or HLA-Bw4
alleles. In addition, EBV-negative donors presented with a history of tonsillectomy more …
protection in the remaining∼ 5% remain unknown. In an exploratory study, we assessed
immunogenetic factors and tonsillectomy in a cohort of 17 EBV-negative and 39 EBV-
positive healthy individuals aged> 60 years. Analyses of HLA genotypes revealed an
association between EBV negativity and the presence of HLA-C-35T/T and/or HLA-Bw4
alleles. In addition, EBV-negative donors presented with a history of tonsillectomy more …
Abstract
Epstein-Barr virus (EBV) infects ∼95% of the adult population. The factors that confer protection in the remaining ∼5% remain unknown. In an exploratory study, we assessed immunogenetic factors and tonsillectomy in a cohort of 17 EBV-negative and 39 EBV-positive healthy individuals aged >60 years. Analyses of HLA genotypes revealed an association between EBV negativity and the presence of HLA-C-35T/T and/or HLA-Bw4 alleles. In addition, EBV-negative donors presented with a history of tonsillectomy more often than EBV-positive donors.
American Society for Microbiology