Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder
characterized by bilateral fluid-filled cysts, renal inflammation and extensive fibrosis, leading
to the progressive decline in kidney function. Renal cyst formation begins in utero from
aberrant proliferation of tubule epithelial cells; however, the mechanisms for cystogenesis
remain unclear. Cell proliferation and Cl−-dependent fluid secretion, which drives the
accumulation of cyst fluid, are responsible for inexorable growth of cysts and the remarkable …