Oxidative stress is a major factor in inflammatory, malignant and metabolic diseases in
domestic and farm animals. Oxidative stress-mediated damage depends on the level of
cellular and total body iron status because an excess iron (Fe2+) pool produces the most
harmful free radicals (hydroxyls) through the Fenton reaction. Ferritin is a ubiquitous and
conserved iron storage protein that plays a central role in iron metabolism and has the dual
function of storing iron in bioavailable and non-toxic forms. Intracellular ferritin synthesis is …