[HTML][HTML] Tonotopy in calcium homeostasis and vulnerability of cochlear hair cells
R Fettiplace, JH Nam - Hearing research, 2019 - Elsevier
Ototoxicity, noise overstimulation, or aging, can all produce hearing loss with similar
properties, in which outer hair cells (OHCs), principally those at the high-frequency base of
the cochlea, are preferentially affected. We suggest that the differential vulnerability may
partly arise from differences in Ca 2+ balance among cochlear locations. Homeostasis is
determined by three factors: Ca 2+ influx mainly via mechanotransducer (MET) channels;
buffering by calcium-binding proteins and organelles like mitochondria; and extrusion by the …
properties, in which outer hair cells (OHCs), principally those at the high-frequency base of
the cochlea, are preferentially affected. We suggest that the differential vulnerability may
partly arise from differences in Ca 2+ balance among cochlear locations. Homeostasis is
determined by three factors: Ca 2+ influx mainly via mechanotransducer (MET) channels;
buffering by calcium-binding proteins and organelles like mitochondria; and extrusion by the …