Adrenergic receptor density in brown adipose tissue of active and hibernating hamsters and ground squirrels
LI Kramarova, GE Bronnikov, DA Ignat'ev… - … and Physiology Part A …, 2007 - Elsevier
The ligand-binding characteristics (Bmax and KD) of α1-and β1/β2-adrenoceptors were
investigated in membranes prepared from brown adipose tissue (BAT) of warm-acclimated,
cold-acclimated, hibernating and arousing ground squirrels (Spermophillus undulatus) and
hamsters (Mesocricetus auratus) by specific binding of [3H] prazosin and [3H] CGP-12177,
respectively. The physiological state did not change the affinity for the adrenoceptors in the
BAT of ground squirrels and hamsters. There was a significant decrease in α1-receptor …
investigated in membranes prepared from brown adipose tissue (BAT) of warm-acclimated,
cold-acclimated, hibernating and arousing ground squirrels (Spermophillus undulatus) and
hamsters (Mesocricetus auratus) by specific binding of [3H] prazosin and [3H] CGP-12177,
respectively. The physiological state did not change the affinity for the adrenoceptors in the
BAT of ground squirrels and hamsters. There was a significant decrease in α1-receptor …