Antibodies targeting BTLA or TIM-3 enhance HIV-1 specific T cell responses in combination with PD-1 blockade
K Grabmeier-Pfistershammer, C Stecher, M Zettl… - Clinical …, 2017 - Elsevier
Persistent stimulation with antigens derived from viruses that establish chronic infections or
tumour antigens results in the exhaustion of T cells. Coinhibitory receptors like PD-1 and
CTLA-4 function as immune checkpoints on exhausted T cells. Blocking these molecules
with antibodies improve immunity to cancer cells. Immune checkpoint inhibitors targeting
other coinhibitory receptors might have a similar role in improving T cell function and thus
also utility in cancer therapy. Using HIV-specific T cells as a model for exhaustion we have …
tumour antigens results in the exhaustion of T cells. Coinhibitory receptors like PD-1 and
CTLA-4 function as immune checkpoints on exhausted T cells. Blocking these molecules
with antibodies improve immunity to cancer cells. Immune checkpoint inhibitors targeting
other coinhibitory receptors might have a similar role in improving T cell function and thus
also utility in cancer therapy. Using HIV-specific T cells as a model for exhaustion we have …