Inhibition of activin receptor-like kinase 5 attenuates bleomycin-induced pulmonary fibrosis
H Higashiyama, D Yoshimoto, T Kaise… - … and molecular pathology, 2007 - Elsevier
Activin receptor-like kinase 5 (ALK5) is a type I receptor of transforming growth factor (TGF)-
beta. ALK5 inhibition has been reported to attenuate the tissue fibrosis including pulmonary
fibrosis, renal fibrosis and liver fibrosis. To elucidate the inhibitory mechanism of ALK5
inhibitor on pulmonary fibrosis in vivo, we performed the histopathological assessment,
gene expression analysis of extracellular matrix (ECM) genes and immunohistochemistry
including receptor-activated Smads (R-Smads; Smad2/3), CTGF, myofibroblast marker …
beta. ALK5 inhibition has been reported to attenuate the tissue fibrosis including pulmonary
fibrosis, renal fibrosis and liver fibrosis. To elucidate the inhibitory mechanism of ALK5
inhibitor on pulmonary fibrosis in vivo, we performed the histopathological assessment,
gene expression analysis of extracellular matrix (ECM) genes and immunohistochemistry
including receptor-activated Smads (R-Smads; Smad2/3), CTGF, myofibroblast marker …