IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors
K Honda, T Taniguchi - Nature Reviews Immunology, 2006 - nature.com
K Honda, T Taniguchi
Nature Reviews Immunology, 2006•nature.comThe interferon-regulatory factor (IRF) family of transcription factors was initially found to be
involved in the induction of genes that encode type I interferons. IRFs have now been shown
to have functionally diverse roles in the regulation of the immune system. Recently, the
crucial involvement of IRFs in innate and adaptive immune responses has been gaining
much attention, particularly with the discovery of their role in immunoregulation by Toll-like
receptors and other pattern-recognition receptors.
involved in the induction of genes that encode type I interferons. IRFs have now been shown
to have functionally diverse roles in the regulation of the immune system. Recently, the
crucial involvement of IRFs in innate and adaptive immune responses has been gaining
much attention, particularly with the discovery of their role in immunoregulation by Toll-like
receptors and other pattern-recognition receptors.
Abstract
The interferon-regulatory factor (IRF) family of transcription factors was initially found to be involved in the induction of genes that encode type I interferons. IRFs have now been shown to have functionally diverse roles in the regulation of the immune system. Recently, the crucial involvement of IRFs in innate and adaptive immune responses has been gaining much attention, particularly with the discovery of their role in immunoregulation by Toll-like receptors and other pattern-recognition receptors.
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