Role of Ca2+ signaling in the regulation of endothelial permeability
C Tiruppathi, RD Minshall, BC Paria, SM Vogel… - Vascular …, 2002 - Elsevier
The vascular endothelial cell forms a semipermeable barrier between blood and interstitium.
Inflammatory mediators such as thrombin and histamine induce vascular leakage defined as
increased endothelial permeability to plasma proteins and other solutes. Increased
endothelial permeability is the hallmark of inflammatory vascular edema. Inflammatory
mediators that bind to heptahelical G protein-coupled receptors (GPCR) trigger increased
endothelial permeability by increasing the intracellular Ca2+ concentration ([Ca2+] i). The …
Inflammatory mediators such as thrombin and histamine induce vascular leakage defined as
increased endothelial permeability to plasma proteins and other solutes. Increased
endothelial permeability is the hallmark of inflammatory vascular edema. Inflammatory
mediators that bind to heptahelical G protein-coupled receptors (GPCR) trigger increased
endothelial permeability by increasing the intracellular Ca2+ concentration ([Ca2+] i). The …
