[HTML][HTML] Pseudomonas Exotoxin A: optimized by evolution for effective killing
M Michalska, P Wolf - Frontiers in microbiology, 2015 - frontiersin.org
M Michalska, P Wolf
Frontiers in microbiology, 2015•frontiersin.orgPseudomonas Exotoxin A (PE) is the most toxic virulence factor of the pathogenic bacterium
Pseudomonas aeruginosa. This review describes current knowledge about the intoxication
pathways of PE. Moreover, PE represents a remarkable example for pathoadaptive
evolution, how bacterial molecules have been structurally and functionally optimized under
evolutionary pressure to effectively impair and kill their host cells.
Pseudomonas aeruginosa. This review describes current knowledge about the intoxication
pathways of PE. Moreover, PE represents a remarkable example for pathoadaptive
evolution, how bacterial molecules have been structurally and functionally optimized under
evolutionary pressure to effectively impair and kill their host cells.
Pseudomonas Exotoxin A (PE) is the most toxic virulence factor of the pathogenic bacterium Pseudomonas aeruginosa. This review describes current knowledge about the intoxication pathways of PE. Moreover, PE represents a remarkable example for pathoadaptive evolution, how bacterial molecules have been structurally and functionally optimized under evolutionary pressure to effectively impair and kill their host cells.
Frontiers