[HTML][HTML] Endothelial barrier strengthening by activation of focal adhesion kinase
SK Quadri, M Bhattacharjee, K Parthasarathi… - Journal of Biological …, 2003 - ASBMB
Endothelial cell barrier (EC) properties regulate blood tissue fluid flux. To determine the role
of endothelial-matrix interactions in barrier regulation, we induced cell shrinkage by
exposing confluent endothelial monolayers to hyperosmolarity. The dominant effect of a 15-
min hyperosmolar exposure was an increase in the trans-endothelial electrical resistance,
indicating the induction of barrier strengthening. Hyperosmolar exposure also increased
activity of focal adhesion kinase and E-cadherin accumulation at the cell periphery …
of endothelial-matrix interactions in barrier regulation, we induced cell shrinkage by
exposing confluent endothelial monolayers to hyperosmolarity. The dominant effect of a 15-
min hyperosmolar exposure was an increase in the trans-endothelial electrical resistance,
indicating the induction of barrier strengthening. Hyperosmolar exposure also increased
activity of focal adhesion kinase and E-cadherin accumulation at the cell periphery …