Pluripotent stem cell-derived cardiomyocytes for treatment of cardiomyopathic damage: current concepts and future directions
JC Garbern, GO Escalante, RT Lee - Trends in Cardiovascular Medicine, 2021 - Elsevier
Today, cell replacement therapy using pluripotent stem cell-derived cardiomyocytes (PSC-
CMs) remains a research endeavor, with several hurdles that must be overcome before
delivery of PSC-CMs can become a therapeutic reality. In this review, we highlight major
findings to date from pre-clinical studies involving delivery of PSC-CMs and consider
remaining challenges that must be addressed for successful clinical translation. Our goal is
to provide an overview of the current status of cardiomyocyte replacement therapy and what …
CMs) remains a research endeavor, with several hurdles that must be overcome before
delivery of PSC-CMs can become a therapeutic reality. In this review, we highlight major
findings to date from pre-clinical studies involving delivery of PSC-CMs and consider
remaining challenges that must be addressed for successful clinical translation. Our goal is
to provide an overview of the current status of cardiomyocyte replacement therapy and what …