[HTML][HTML] Suppression by metallothionein of doxorubicin-induced cardiomyocyte apoptosis through inhibition of p38 mitogen-activated protein kinases
YJ Kang, ZX Zhou, GW Wang, A Buridi… - Journal of Biological …, 2000 - ASBMB
Cardiomyopathy induced by doxorubicin (DOX) has long been a major impediment of
clinical applications of this effective anticancer agent. Previous studies have shown that
cardiac-specific metallothionein (MT)-overexpressing transgenic mice are highly resistant to
DOX-induced cardiotoxicity. To investigate cellular and molecular mechanisms by which MT
participates in this cytoprotection, transgenic mice containing high levels of cardiac MT and
non-transgenic controls were treated intraperitoneally with DOX at a single dose of 15 mg/kg …
clinical applications of this effective anticancer agent. Previous studies have shown that
cardiac-specific metallothionein (MT)-overexpressing transgenic mice are highly resistant to
DOX-induced cardiotoxicity. To investigate cellular and molecular mechanisms by which MT
participates in this cytoprotection, transgenic mice containing high levels of cardiac MT and
non-transgenic controls were treated intraperitoneally with DOX at a single dose of 15 mg/kg …