Ultrastructural Aspects of the Goiter in cog/cog Mice
A Mayerhofer, AG Amador, WG Beamer… - Journal of …, 1988 - academic.oup.com
A Mayerhofer, AG Amador, WG Beamer, A Bartke
Journal of Heredity, 1988•academic.oup.comThyroids of congenitally goitrous (cog/cog) mice were studied with light and electron
microscopy. The principal alteration in follicular cells was their largely overdistended rough
endoplasmic reticulum (RER). Our findings resemble the ultrastructural features of human
hypothyroid goiter caused by a thyroglobulin (TG) defect and thus support the previously
suggested abnormalities of TG synthesis and/or processing in cog/cog mice.
microscopy. The principal alteration in follicular cells was their largely overdistended rough
endoplasmic reticulum (RER). Our findings resemble the ultrastructural features of human
hypothyroid goiter caused by a thyroglobulin (TG) defect and thus support the previously
suggested abnormalities of TG synthesis and/or processing in cog/cog mice.
Abstract
Thyroids of congenitally goitrous (cog/cog) mice were studied with light and electron microscopy. The principal alteration in follicular cells was their largely overdistended rough endoplasmic reticulum (RER). Our findings resemble the ultrastructural features of human hypothyroid goiter caused by a thyroglobulin (TG) defect and thus support the previously suggested abnormalities of TG synthesis and/or processing in cog/cog mice.
Oxford University Press