G0/G1 switch gene-2 regulates human adipocyte lipolysis by affecting activity and localization of adipose triglyceride lipase
M Schweiger, M Paar, C Eder, J Brandis, E Moser… - Journal of lipid …, 2012 - jlr.org
The hydrolysis of triglycerides in adipocytes, termed lipolysis, provides free fatty acids as
energy fuel. Murine lipolysis largely depends on the activity of adipose triglyceride lipase
(ATGL), which is regulated by two proteins annotated as comparative gene identification-58
(CGI-58) and G0/G1 switch gene-2 (G0S2). CGI-58 activates and G0S2 inhibits ATGL
activity. In contrast to mice, the functional role of G0S2 in human adipocyte lipolysis is poorly
characterized. Here we show that overexpression or silencing of G0S2 in human SGBS …
energy fuel. Murine lipolysis largely depends on the activity of adipose triglyceride lipase
(ATGL), which is regulated by two proteins annotated as comparative gene identification-58
(CGI-58) and G0/G1 switch gene-2 (G0S2). CGI-58 activates and G0S2 inhibits ATGL
activity. In contrast to mice, the functional role of G0S2 in human adipocyte lipolysis is poorly
characterized. Here we show that overexpression or silencing of G0S2 in human SGBS …