A targeted apolipoprotein B-38.9-producing mutation causes fatty livers in mice due to the reduced ability of apolipoprotein B-38.9 to transport triglycerides
Z Chen, RL Fitzgerald, MR Averna… - Journal of Biological …, 2000 - jbc.org
Nonphysiological truncations of apolipoprotein (apo) B-100 cause familial
hypobetalipoproteinemia (FHBL) in humans and mice. An elucidation of the mechanisms
underlying the FHBL phenotypes may provide valuable information on the metabolism of
apo B-containing lipoproteins and the structure-function relationship of apo B. To generate a
faithful mouse model of human FHBL, a subtle mutation was introduced into the mouse apo
B gene by targeting embryonic stem cells using homologous recombination followed by …
hypobetalipoproteinemia (FHBL) in humans and mice. An elucidation of the mechanisms
underlying the FHBL phenotypes may provide valuable information on the metabolism of
apo B-containing lipoproteins and the structure-function relationship of apo B. To generate a
faithful mouse model of human FHBL, a subtle mutation was introduced into the mouse apo
B gene by targeting embryonic stem cells using homologous recombination followed by …
