The LXR agonist T0901317 promotes the reverse cholesterol transport from macrophages by increasing plasma efflux potential
The liver X receptors (LXRs) have been shown to affect lipoprotein plasma profile, lipid
metabolism, and reverse cholesterol transport (RCT). In the present study, we investigated
whether a short-term administration of the synthetic LXR agonist T0901317 (T0) to mice may
affect RCT by modulating the capacity of plasma to promote cellular lipid efflux. Consistent
with previous data, the pharmacological treatment of mice caused a significant increase of
macrophage-derived [3 H] cholesterol content in plasma, liver, and feces and resulted in …
metabolism, and reverse cholesterol transport (RCT). In the present study, we investigated
whether a short-term administration of the synthetic LXR agonist T0901317 (T0) to mice may
affect RCT by modulating the capacity of plasma to promote cellular lipid efflux. Consistent
with previous data, the pharmacological treatment of mice caused a significant increase of
macrophage-derived [3 H] cholesterol content in plasma, liver, and feces and resulted in …