Liver X receptor activation promotes macrophage-to-feces reverse cholesterol transport in a dyslipidemic hamster model
F Briand, M Tréguier, A André, D Grillot, M Issandou… - Journal of lipid …, 2010 - jlr.org
Liver X receptor (LXR) activation promotes reverse cholesterol transport (RCT) in rodents
but has major side effects (increased triglycerides and LDL-cholesterol levels) in species
expressing cholesteryl ester transfer protein (CETP). In the face of dyslipidemia, it remains
unclear whether LXR activation stimulates RCT in CETP species. We therefore used a
hamster model made dyslipidemic with a 0.3% cholesterol diet and treated with vehicle or
LXR agonist GW3965 (30 mg/kg bid) over 10 days. To investigate RCT, radiolabeled 3 H …
but has major side effects (increased triglycerides and LDL-cholesterol levels) in species
expressing cholesteryl ester transfer protein (CETP). In the face of dyslipidemia, it remains
unclear whether LXR activation stimulates RCT in CETP species. We therefore used a
hamster model made dyslipidemic with a 0.3% cholesterol diet and treated with vehicle or
LXR agonist GW3965 (30 mg/kg bid) over 10 days. To investigate RCT, radiolabeled 3 H …
