[HTML][HTML] Accelerated fatty acid oxidation in muscle averts fasting-induced hepatic steatosis in SJL/J mice

HP Guan, JL Goldstein, MS Brown, G Liang - Journal of biological chemistry, 2009 - ASBMB
The accumulation of triglycerides (TG) in the liver, designated hepatic steatosis, is
characteristically associated with obesity and insulin resistance, but it can also develop after
fasting. Here, we show that fasting-induced hepatic steatosis is under genetic control in
inbred mice. After a 24-h fast, C57BL/6J mice and SJL/J mice both lost more than 20% of
body weight and∼ 60% of total body TG. In C57BL/6J mice, TG accumulated in liver,
producing frank steatosis. In striking contrast, SJL/J mice failed to accumulate any hepatic …