Fasting causes lipolysis in adipose tissue leading to the release of large quantities of free
fatty acids into circulation that reach the liver where they are metabolized to generate ketone
bodies to serve as fuels for other tissues. Since fatty acid-metabolizing enzymes in the liver
are transcriptionally regulated by peroxisome proliferator-activated receptor α (PPARα), we
investigated the role of PPARα in the induction of these enzymes in response to fasting and
their relationship to the development of hepatic steatosis in mice deficient in PPARα …