This work describes the molecular mechanisms of fatty acid and hormonal modulations of
the retinoid X receptor α (RXRα) in rat liver cells. We examined the effects of different fatty
acids (myristic, stearic, oleic, linolenic, and arachidonic acids, EPA, and the peroxisomal
proliferator TTA) and several hormones (the glucocorticoid analogue dexamethasone,
insulin, and retinoic acid) on the RXRα mRNA and protein levels in rat hepatoma cells and
cultured hepatocytes. The fatty acids induced the RXRα gene expression resulting in up to 3 …