Regulation of energy metabolism by long-chain fatty acids
MT Nakamura, BE Yudell, JJ Loor - Progress in lipid research, 2014 - Elsevier
In mammals, excess energy is stored primarily as triglycerides, which are mobilized when
energy demands arise. This review mainly focuses on the role of long chain fatty acids
(LCFAs) in regulating energy metabolism as ligands of peroxisome proliferator-activated
receptors (PPARs). PPAR-alpha expressed primarily in liver is essential for metabolic
adaptation to starvation by inducing genes for beta-oxidation and ketogenesis and by
downregulating energy expenditure through fibroblast growth factor 21. PPAR-delta is highly …
energy demands arise. This review mainly focuses on the role of long chain fatty acids
(LCFAs) in regulating energy metabolism as ligands of peroxisome proliferator-activated
receptors (PPARs). PPAR-alpha expressed primarily in liver is essential for metabolic
adaptation to starvation by inducing genes for beta-oxidation and ketogenesis and by
downregulating energy expenditure through fibroblast growth factor 21. PPAR-delta is highly …